Award
National Institute on Aging 5R01AG082748-04
Cytosolic SINE retrotransposable element cDNA and mitochondrial DNA in aging retina
Recipient
University of Virginia, Charlottesville, VA
Award Amount
$631,751.00
Ceiling
$631,751.00
Awarded
April 03, 2026
Identifier
5R01AG082748-04
Research project funded by the National Institute on Aging to study the role of cytosolic DNAs in retinal aging and diseases like AMD, aiming to develop new therapeutic strategies.
Description
The project investigates how cytosolic DNAs, specifically SINE RTE DNA and mitochondrial DNA, contribute to retinal cell death in aging-related diseases such as AMD. It aims to map the sequence and expression of Alu cDNAs and mtDNA during aging, explore their biogenesis regulation, and elucidate pathways leading to cellular dysfunction and death.