Award
National Institute of Environmental Health Sciences 1R15ES033393-01A1
PCB-induced priming of microglial activity across sexes and development
Recipient
De Paul University, Chicago, IL, United States
Award Amount
$446,852.00
Ceiling
$446,852.00
Awarded
July 29, 2022
Identifier
1R15ES033393-01A1
Research project funded by NIEHS to study how PCBs affect microglial immune cells in the brain differently by sex and age, to understand environmental impacts on neurodevelopmental and mood disorders.
Description
The project aims to identify direct effects and mechanisms of PCB action on microglial function and possible neuronal consequences, focusing on sex- and age-specific responses. It involves isolating microglia from neonatal and adolescent brains, treating them with PCBs, and analyzing cytokine signaling, oxidative stress, and phagocytosis. The study is innovative in examining sex differences in microglial responses to environmental toxicants and aims to inform therapeutic strategies and exposure mitigation.