Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5K08AR077100-05
The Retroelement LINE1 and the DNA Sensor IF16 in Sjogren's Syndrome
Recipient
Johns Hopkins University, Baltimore, MD, United States
Award Amount
$158,755.00
Ceiling
$158,755.00
Awarded
February 18, 2025
Identifier
5K08AR077100-05
Research project funded to study the role of retroelement LINE1 and DNA sensor IFI16 in the autoimmune disease Sjögren's Syndrome, aiming to understand immune activation and potential therapeutic pathways.
Description
This project seeks to determine whether the retroelement LINE1 activates the immune system in a way that contributes to autoimmunity in Sjögren’s Syndrome. This work could help explain how dysregulated immune surveillance of endogenous genetic material could promote autoimmunity in some people. Completion of this work may help direct study of new targeted therapies for Sjögren’s Syndrome and related rheumatic diseases.