Award
NIH Reporter #11320824
Neurodevelopmental Mechanisms Underlying the Onset of Depression Amount At-Risk Youth: The Role of Dysregulation in the Negative Valence System
Recipient
National Institute of Mental Health (NIMH)
Award Amount
$567,931.00
Ceiling
$567,931.00
Awarded
February 25, 2026
Identifier
11320824
This award funds a research project by the National Institute of Mental Health to study neurodevelopmental mechanisms underlying depression onset in at-risk youth, aiming to identify biomarkers and risk factors through longitudinal multimodal assessments.
Description
The project focuses on studying neurodevelopmental mechanisms related to depression in youth at risk, using multimodal longitudinal methods including fMRI, ERPs, and behavioral assessments. The project aims to identify biomarkers and risk markers for depression, and explore how biological sex and puberty interact with neurodevelopmental pathways. The study will recruit 250 youth aged 9-14, with and without maternal history of recurrent MDD. The project involves collaboration with the Pennsylvania State University and is funded by NIH grant PA-20-185. The project duration is from May 2023 to February 2028.