Award
National Institute of Allergy and Infectious Diseases 4R01AI169296-04
Lipid mediated oral tolerance
Recipient
State University of New York at Buffalo, Amherst, NY
Award Amount
$931,012.00
Ceiling
$931,012.00
Awarded
June 09, 2025
Identifier
4R01AI169296-04
The award funds research to develop lipid-based nanoparticle immunotherapy to induce oral tolerance and treat autoimmune diseases, allergies, and immunogenicity against therapeutic proteins.
Description
This project aims to develop an immunotherapy platform using protein delivery strategies to treat autoimmune conditions, food allergies, and immunogenicity against therapeutic proteins. The research focuses on understanding the cellular and molecular mechanisms of oral delivery and tolerance mediated by lyso-phosphatidylserine (lysoPS) based nanoparticles. The goal is to elucidate how biophysical properties of lipidic particles influence immune responses, receptor interactions, and cellular uptake, ultimately leading to clinical strategies to reduce immunogenicity and autoimmunity.