Award
National Institute of Allergy and Infectious Diseases 1R01AI187392-01A1
New potent orally bioavailable nitro-containing compounds to treat mycobacterial infections
Recipient
Michigan State University
Award Amount
$2,248,740.00
Ceiling
$2,248,740.00
Awarded
July 07, 2025
Identifier
1R01AI187392-01A1
NIH awarded a grant to Michigan State University for developing new orally bioavailable nitro-containing compounds to treat mycobacterial infections, including tuberculosis. The project involves pharmacokinetic and efficacy studies over a 3-year period with funding of approximately $2.25 million.
Description
The project focuses on developing new nitrofurans as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus. The project includes SAR studies, pharmacokinetic studies, and in vivo efficacy testing. The project aims to address the urgent need for new treatments for tuberculosis and non-tuberculous mycobacterial infections.