Award
National Cancer Institute 5F30CA298683-02
Novel Approach to Hepatocellular Carcinoma Treatment through Enhanced ER Stress
Recipient
University of Texas Health Science Center
Award Amount
$39,646.00
Ceiling
$39,646.00
Awarded
February 05, 2026
Identifier
5F30CA298683-02
NIH awarded a grant to University of Texas Health Science Center for research on a novel therapy for hepatocellular carcinoma using ERX-315 to induce ER stress and apoptosis in cancer cells.
Description
This NIH grant supports research on novel therapeutic strategies for liver cancer, focusing on ER stress mechanisms and targeted small molecules. The project aims to develop a novel therapy using ERX-315, a small molecule that promotes endoplasmic reticulum stress in cancer cells, leading to apoptosis. The study will evaluate the biological activity of ERX-315, determine its efficacy in blocking HCC progression, test its ability to induce ER stress and apoptosis in patient-derived models, investigate its biochemical mechanisms, and define molecular mechanisms of ERX-315 binding to LIPA.