Award
NIH Reporter #1K99NS150641-01
Macrophage remodeling of brain extracellular matrix in Krabbe disease
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$128,925.00
Ceiling
$128,925.00
Awarded
August 07, 2026
Identifier
1K99NS150641-01
NIH grant awarded to University of Pennsylvania to study macrophage roles in brain ECM remodeling in Krabbe disease, aiming to find new intervention strategies.
Description
This project focuses on understanding how macrophages remodel brain extracellular matrix (ECM) and alter tissue mechanics in Krabbe disease, a pediatric leukodystrophy. The research aims to identify new intervention strategies to support healing by studying ECM production and remodeling by microglia, a type of brain macrophage.