National Institute of Biomedical Imaging and Bioengineering 11344537

Magnetic resonance imaging methods to capture tolerogenic cell therapy fate in preclinical and ex vivo human transplant models

The project develops MRI-based methods to track immunomodulatory cell therapies in organ transplantation models, aiming to improve graft survival and immune tolerance.

Description

This project aims to develop animal models of solid organ transplantation followed by cell therapy delivery and longitudinal tracking of infused cells by MRI. Leveraging discarded human donor organs, the project will create a clinically relevant MRI-based cell tracking platform to monitor infused regulatory T cells (Tregs) and other immunomodulatory cells such as M2 macrophages and engineered dendritic cells in real time. The goal is to study their distribution, retention, and interaction within vascular and tissue compartments, ultimately helping to overcome obstacles to achieving durable immune tolerance and long-term graft survival.

View original record