Award
National Heart, Lung, and Blood Institute 5P01HL131477-09
Project 1 - Molecular and cellular determinants of hematopoietic clonal expansion
Recipient
Massachusetts General Hospital
Award Amount
$405,398.00
Ceiling
$405,398.00
Awarded
May 19, 2026
Identifier
5P01HL131477-09
This NIH-funded project studies the molecular and cellular factors that drive clonal expansion in hematopoiesis, aiming to uncover mechanisms of clonal dominance and potential therapeutic targets.
Description
The project investigates the mechanisms of clonal hematopoiesis (CH), focusing on how certain hematopoietic progenitors gain and maintain a competitive advantage. Using high-resolution cellular barcoding and novel mouse models, the study aims to understand the molecular determinants of clonal dominance and identify targets to manipulate clonal competition.