Award
NIH Reporter #5R01NS088137-12
Targeting TGFb/IFNy-IRF8 Signaling to Modulate Monocytes and their Crosstalk with Microglia and Astrocytes to Treat Multiple Sclerosis
Recipient
Brigham and Women's Hospital, Boston, MA, United States
Award Amount
$644,207.00
Ceiling
$644,207.00
Awarded
April 13, 2026
Identifier
5R01NS088137-12
Research project funded by NINDS to study TGFb/IFNg-IRF8 signaling in monocyte and glial cell interactions to develop new treatments for multiple sclerosis.
Description
This proposal investigates the role of TGFb/IFNg-IRF8 signaling in monocyte-astrocyte-microglia crosstalk as a target to treat multiple sclerosis (MS). It aims to modulate this signaling pathway to influence disease progression and validate findings with MS monocytes and humanized mice.