Award
Wisconsin Department of Veterans Affairs 5I01CX002308-05
Planar Cell Polarity Control in Melanoma Metastasis
Recipient
WM S. MIDDLETON MEMORIAL VETERANS HOSP
Awarded
June 01, 2026
Identifier
5I01CX002308-05
Research project investigating the role of the FZD6 gene in melanoma metastasis to develop targeted therapies, focusing on melanoma cell invasion, metastasis in vivo, and clinical significance.
Description
The project aims to investigate the role of the PCP pathway, specifically the gene FZD6, in melanoma invasion and metastasis. Preliminary studies show FZD6 overexpression in melanoma cells, and its knockout reduces metastasis in mouse models. The research will explore mechanisms of FZD6 in vitro, its significance in vivo, and its clinical relevance, with the goal of developing targeted therapies.