Award
National Institute on Aging 5K01AG086542-02
Dysfunctional mechanisms of the mitochondrial redox-sensitive signaling response to exercise in aged skeletal muscle
Recipient
University of Washington, Seattle, WA
Award Amount
$120,584.00
Ceiling
$120,584.00
Awarded
June 19, 2026
Identifier
5K01AG086542-02
NIH grant awarded to University of Washington to study mitochondrial redox signaling dysfunction in aged skeletal muscle and its role in sarcopenia, using advanced models and aiming to develop therapeutic targets.
Description
This project explores the dysfunctional mechanisms of mitochondrial redox signaling in aged skeletal muscle, focusing on substrate utilization, beta oxidation, TCA cycle flux, and mitochondrial protein interactions. The research will utilize novel 3D engineered tissues and in vivo mouse models. The project aims to identify redox-sensitive signaling mechanisms following muscle contraction affected by age, which may serve as targets for therapeutics to decrease or reverse sarcopenia.