National Institute of General Medical Sciences 5R35GM155168-03

Pharmacomicrobiomics: The Frontier of Interindividual Variability in Drug Response

Research grant awarded to University of North Carolina Chapel Hill to study bacterial drug metabolism and its impact on drug response variability, focusing on β-glucuronidase enzyme and integrating findings into pharmacokinetic models.

Description

This grant supports research on bacterial drug metabolism, focusing on the enzyme β-glucuronidase, to understand and mitigate drug toxicity related to microbiome interactions. The project includes developing phenotypic biomarkers and integrating bacterial metabolism into pharmacokinetic models for better prediction of drug responses.

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