Award
National Institute of Allergy and Infectious Diseases 5R01AI155545-05
Anti-inflammatory functions for non-transcriptional IRF3
Recipient
University of Kentucky, Lexington, KY
Award Amount
$420,465.00
Ceiling
$420,465.00
Awarded
January 30, 2026
Identifier
5R01AI155545-05
This NIH-funded project studies the non-transcriptional anti-inflammatory role of IRF3 in immune response regulation, focusing on its interaction with NF-κB to prevent inflammation and viral pathogenesis.
Description
The project aims to investigate the anti-inflammatory functions of the host transcription factor IRF3, particularly its non-transcriptional role in modulating immune responses to viral and non-viral stimuli. The research hypothesizes that IRF3 interacts with NF-κB to inhibit inflammatory gene induction, thereby preventing inflammatory pathogenesis.