Award
NIH Reporter #1R35GM166453-01
Probing Cell Signaling Complexity in Wound Healing with Engineered Protein Materials
Recipient
University of New England, Biddeford, ME, United States
Award Amount
$390,500.00
Ceiling
$390,500.00
Awarded
August 24, 2026
Identifier
1R35GM166453-01
Research project funded by NIGMS to study protein-receptor interactions in wound healing using engineered protein materials, focusing on VEGFR1 and Nrp1 receptors and their role in cell signaling and healing processes.
Description
This project aims to investigate how ligand presentation affects receptor binding, signaling, and trafficking using engineered elastin-like protein polymers that bind VEGFR1 and Nrp1. The research will explore receptor interactions in different molecular contexts, develop new biomaterials, and utilize the kidney as an internal model for studying wound healing.