Award
NIH Reporter #11282284
From Atoms to Organoids: Understanding the Conformational Landscape and Regulation of Small GTPases
Recipient
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Award Amount
$141,566.00
Ceiling
$141,566.00
Awarded
March 26, 2026
Identifier
11282284
Research project awarded by the National Cancer Institute to the University of Pittsburgh to study small GTPases in cancer using advanced structural biology and organoid models, aiming to develop therapeutic tools.
Description
The project focuses on elucidating the mechanism of hydrolysis in oncogenic RhoA, regulation by GDIs, and their role in cancer. It involves structural biology techniques such as time-resolved X-ray crystallography and NMR, as well as in-cell and organoid studies. The goal is to develop tools for targeting small GTPases in cancer therapy.