Award
National Institute of Allergy and Infectious Diseases 5U19AI174994-04
Oklahoma C. difficile U19 Challenge Core
Recipient
University of Oklahoma Health Sciences Center, Oklahoma City, OK
Award Amount
$76,676.00
Ceiling
$76,676.00
Awarded
June 30, 2026
Identifier
5U19AI174994-04
This award funds the development of a standardized 'Challenge Core' to support vaccine efficacy testing for C. difficile using murine and hamster models, facilitating research across multiple projects.
Description
The central goal of the Oklahoma C. difficile U19 program is to advance a second-generation vaccine for C. difficile by revealing mechanisms that limit protective vaccine-induced responses. To achieve this, challenge experiments using relevant animal models are required to test vaccine efficacy. The program includes three research projects that will benefit from a standardized 'Challenge Core' service. This core will develop and provide murine and hamster challenge models, ensuring standardization and experimental rigor, and will be accessible to other investigators.