Award
National Institute of Allergy and Infectious Diseases 1R01AI194527-01A1
Investigating the nonlinear complex dynamics of the tuft cell-microbiome cross-talk: the impact of feedback loops on immune regulation, microbial modulation and response to tissue insults
Recipient
University of Massachusetts Medical School Worcester, MA, United States
Award Amount
$836,691.00
Ceiling
$836,691.00
Awarded
June 17, 2026
Identifier
1R01AI194527-01A1
Research project funded by NIAID to study the complex interactions between tuft cells, immune regulation, and microbiome in the intestine, aiming to develop models predicting intestinal health outcomes and guide microbiome-targeted therapies.
Description
Tuft cells (TCs) are specialized chemosensory epithelial cells that regulate intestinal homeostasis. This project explores the feedback loops between tuft cells, immune responses, and microbiome interactions, using mathematical modeling and experimental validation to understand intestinal resilience and inform therapeutic strategies.