Award
National Cancer Institute 5R01CA274967-04
Functional Characterization and Development of Therapeutic Paradigms for DNA Damage Repair (DDR)-deficient Lethal Prostate Cancer
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$722,198.00
Ceiling
$722,198.00
Awarded
April 07, 2026
Identifier
5R01CA274967-04
NIH awarded a grant to ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI for research on DNA damage repair gene alterations in lethal prostate cancer, focusing on BRCA2 and developing new therapeutic approaches including immunotherapy and radiotherapy.
Description
This NIH grant supports research on the molecular mechanisms of DDR gene alterations in prostate cancer, with potential therapeutic implications including immunotherapy, radiotherapy, and targeted treatments. The project aims to investigate the role of DNA damage repair gene alterations, particularly BRCA2, in lethal prostate cancer and develop novel combination treatments such as targeted immunotherapy and radiotherapy.