# NIH Reporter #6F31HD114406-04

AAV gene therapy to restore fertility in mammalian Sertoli cell dysfunction models

**Recipient:** University of Pittsburgh at Pittsburgh

**Award Amount:** $50,114.00
**Ceiling:** $50,114.00

**Awarded:** August 27, 2026

**Identifier:** 6F31HD114406-04

NIH grant funding research into AAV gene therapy as a potential treatment for infertility caused by Sertoli cell dysfunction.

### Description

Project to test the feasibility and safety of AAV-mediated Sertoli cell gene therapy to restore fertility in mammalian models of Sertoli cell dysfunction, including evaluating the risk of germline modification and identifying AAV serotypes with Sertoli cell-specific infection in human testicular tissue.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11611167)