Award
NIH Reporter #5R01AI175212-03
Role of T-bet B cells in rheumatoid arthritis
Recipient
University of Rochester, Rochester, NY
Award Amount
$711,221.00
Ceiling
$711,221.00
Awarded
December 23, 2025
Identifier
5R01AI175212-03
Research project studying the role of T-bet expressing B cells in rheumatoid arthritis to understand their impact on joint erosion and inflammation, aiming to develop targeted therapies.
Description
This project evaluates how a novel subset of B cells, expressing the transcription factor T-bet, contribute to ongoing disease activity, inhibit bone-forming osteoblasts, and activate bone-eroding osteoclasts, thus contributing to inflammation and joint destruction in rheumatoid arthritis. The research aims to define how T-bet influences synovial B cell states, mediates B cell-driven bone effects, and coordinates pathogenic functions in RA, potentially leading to new therapies.