Award
NIH Reporter #5R21AI183146-02
Alleviating antibiotic-induced gut dysbiosis by restoring small intestinal bile acid metabolism
Recipient
Brown University, Providence, RI, United States
Award Amount
$199,375.00
Ceiling
$199,375.00
Awarded
December 04, 2025
Identifier
5R21AI183146-02
This award supports research to understand and counteract antibiotic-induced gut microbiome damage by studying bile acid metabolism in the gastrointestinal tract, aiming to develop dietary supplements or pharmacological interventions.
Description
The project focuses on developing therapeutic strategies to mitigate microbiome damage caused by antibiotics, specifically targeting bile acid metabolism. The research involves mouse models and multi-omic datasets to identify intervention points for restoring bile acid metabolism to prevent gut dysbiosis.