Award
National Cancer Institute 11163312
Using natural killer cells to prevent breast cancer metastases
Recipient
UT Southwestern Medical Center
Award Amount
$255,383.00
Ceiling
$255,383.00
Awarded
July 31, 2025
Identifier
11163312
Research project funded by the National Cancer Institute to study natural killer cell function in preventing breast cancer metastases and develop NK cell-based immunotherapies.
Description
This project aims to create novel 3D co-culture assays of NK cells and invasive breast cancer organoids and cell clusters to study NK cell function. The research will investigate how reprogrammed NK cells promote metastasis and how to restore their anti-metastatic activity through molecular and cellular approaches, including CRISPR-Cas9 tools.