Award
National Eye Institute 5R01EY035525-04
Molecular mechanisms of photoreceptor disc morphogenesis
Recipient
Duke University, Durham, NC, United States
Award Amount
$648,451.00
Ceiling
$648,451.00
Awarded
April 02, 2026
Identifier
5R01EY035525-04
Research project funded by the National Eye Institute to study the molecular mechanisms of photoreceptor disc morphogenesis, focusing on actin cytoskeleton regulation and photoreceptor health.
Description
This project aims to elucidate the regulation of actin cytoskeleton dynamics in photoreceptor cells, focusing on the molecular and cellular mechanisms responsible for building and maintaining the light-sensitive outer segment of vertebrate photoreceptor cells. The research uses genetically modified mice and Xenopus frogs to understand photoreceptor cell biology and mechanisms underlying photoreceptor degeneration.