National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR078198-05

Pathophysiology of Myotonia and Periodic Paralysis

NIAMS awarded a research project to study the mechanisms of myotonia and periodic paralysis using genetically-engineered mouse models and computational modeling, with a focus on developing therapeutic interventions. The award amount is about $491,495 for fiscal year 2025.

Description

The project focuses on understanding the mechanisms of periodic paralysis and myotonia, ion channelopathies affecting skeletal muscle. The research involves genetically-engineered mouse models, ion content characterization, and computational modeling. The project aims to develop and test therapeutic interventions. Funding is provided by NIAMS under grant PA-20-185. The project is part of the Skeletal Muscle and Exercise Physiology Study Section (SMEP). The award amount is approximately $491,495 for the fiscal year 2025. The project emphasizes translational research and rare diseases.

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