Award
National Institute on Aging 1R21AG098304-01A1
Genetic Modifiers of Atherosclerosis: Understanding and Targeting the Mechanism of the ApoER2-R952Q Mutation
Recipient
UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX
Award Amount
$456,500.00
Ceiling
$456,500.00
Awarded
May 07, 2026
Identifier
1R21AG098304-01A1
This NIH-funded project studies the ApoER2-R952Q genetic mutation's role in cardiovascular disease, aiming to understand its mechanisms and develop targeted therapies to prevent atherosclerosis and myocardial infarction.
Description
The project investigates the role of the ApoER2-R952Q mutation in promoting cardiovascular disease, focusing on mechanisms involving endothelial adhesion, leukocyte infiltration, and inflammation. It aims to develop targeted therapeutic strategies based on mechanistic insights.