Award
NIH Reporter #11516267
APOE4 dependent regulation of CSF Complement Pathway Activation in the development of Alzheimer's Disease
Recipient
Stanford University
Award Amount
$620,981.00
Ceiling
$620,981.00
Awarded
August 12, 2026
Identifier
11516267
Research project studying how APOE4 affects complement pathway activation in cerebrospinal fluid and its link to Alzheimer's disease risk and cognitive decline, potentially identifying drug targets.
Description
This project aims to evaluate the role of APOE4-related alterations in the complement pathway within human spinal fluid as a potential cause of increased Alzheimer's disease risk, and to understand the relationship between complement pathway activation and cognitive decline over 7.5 years. The work involves advanced protein measurement techniques and may lead to drug targets for prevention.