Award
NIH Reporter #5R01AR081228-05
To explore the molecular and cellular effects of transient DUX4 expression in skeletal muscle
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$323,950.00
Ceiling
$323,950.00
Awarded
August 14, 2026
Identifier
5R01AR081228-05
Research project funded by NIAMS to study the effects of transient DUX4 expression in skeletal muscle using mouse models, aiming to understand its role in muscle degeneration and pathology relevant to FSHD.
Description
This project aims to understand whether transient DUX4 expression is sufficient to trigger degenerative processes or to set up a pro-degenerative state that, together with injury, will lead to a muscle dystrophic phenotype seen in FSHD patients. It will explore the long-lasting effects of transient DUX4 expression on muscle physiology, histology, cellular alterations, and epigenetic state in mouse models.