Award
NIH Reporter #5F30DK131853-05
Investigating siRNA-mediated inhibition of ischemia-reperfusion injury during the liver transplantation process
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$52,007.00
Ceiling
$52,007.00
Awarded
June 29, 2026
Identifier
5F30DK131853-05
The award supports research on using siRNA technology to inhibit ischemia-reperfusion injury in liver transplantation by targeting the Fas receptor, aiming to increase viable donor livers and improve patient survival.
Description
This project aims to use small interfering RNA (siRNA) to inhibit ischemia-reperfusion injury (IRI) and improve the quality of liver grafts for transplantation. The study focuses on silencing hepatocyte-specific Fas receptor to reduce liver damage during transplantation, using chemically-modified siRNAs delivered via N-acetylgalactosamine (GalNAc). The project includes in vivo and ex vivo approaches to assess the effects of Fas silencing on IRI pathways and transplant outcomes.