Award
National Institute of Allergy and Infectious Diseases 5K08AI182474-03
Harnessing machine learning to develop new antibiotics for Neisseria gonorrhoeae
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$196,738.00
Ceiling
$196,738.00
Awarded
February 12, 2026
Identifier
5K08AI182474-03
The award funds a project using machine learning to discover new antibiotics for Neisseria gonorrhoeae, addressing antibiotic resistance through computational and experimental methods.
Description
This project aims to apply machine learning techniques, such as graph neural networks, to identify new antibiotic candidates for Neisseria gonorrhoeae by predicting growth inhibitory activity from chemical structures. The research builds on preliminary screening of 38,000 compounds and plans to screen large chemical libraries in silico, validate in vitro, determine mechanisms of action, and test in vivo efficacy.