Award
National Institute of General Medical Sciences 5R35GM154651-02
Cellular Mechanisms of Lysosomal Damage Response
Recipient
University of New Mexico Health Sciences Center
Award Amount
$381,250.00
Ceiling
$381,250.00
Awarded
August 11, 2025
Identifier
5R35GM154651-02
Research project funded by NIGMS to study how lysosomal damage triggers stress granule formation, aiming to uncover molecular mechanisms and therapeutic targets for related diseases.
Description
This project aims to provide insights into the relationship between lysosomal damage and stress granule formation, with the potential to promote significant therapeutic advancements. It focuses on understanding the cellular response to lysosomal damage and the formation of stress granules, which are membrane-less organelles involved in cell stress responses. The research employs high-content microscopy, lysosome immunoprecipitation, proteomic analysis, and RNAi screening to investigate the molecular mechanisms involved.