Award
National Institute of Allergy and Infectious Diseases 1R21AI190454-01
Innovative Antibiotic Combinations for Hypervirulent Klebsiella pneumoniae
Recipient
University of Illinois at Chicago
Award Amount
$456,911.00
Ceiling
$456,911.00
Awarded
June 26, 2025
Identifier
1R21AI190454-01
The project focuses on developing and validating combination antibiotic therapies targeting hypervirulent and resistant strains of Klebsiella pneumoniae, aiming to overcome capsule-mediated antibiotic resistance through novel approaches including CRISPR interference and pre-clinical mouse models.
Description
This NIH-funded project aims to develop innovative antibiotic strategies against hypervirulent and multidrug-resistant Klebsiella pneumoniae by targeting capsule synthesis and resistance mechanisms, utilizing in vitro, CRISPRi, and pre-clinical models.