Award
National Cancer Institute 5R01CA272934-04
WNT5a/ROR2-Mediated Hippo Pathway Activation in Prostate Cancer
Recipient
Beth Israel Deaconess Medical Center, Boston, MA, United States
Award Amount
$395,509.00
Ceiling
$395,509.00
Awarded
May 26, 2026
Identifier
5R01CA272934-04
This award funds a research project focused on understanding how Wnt5a/ROR2 signaling activates the Hippo pathway to suppress tumor growth in prostate cancer, with the goal of developing targeted therapies using Wnt5a-mimetic drugs for certain prostate cancer patients.
Description
Research project investigating the role of Wnt5a/ROR2 signaling in activating the Hippo pathway to suppress YAP1/TAZ activity in prostate cancer, aiming to identify biomarkers and assess therapeutic potential of Wnt5a-mimetic drugs for metastatic castration-resistant prostate cancer (mCRPC).