Award
National Heart, Lung, and Blood Institute 5R01HL175502-02
Mito-inflammation and sepsis-induced acute lung injury
Recipient
Florida International University, Miami, FL, United States
Award Amount
$680,510.00
Ceiling
$680,510.00
Awarded
June 11, 2026
Identifier
5R01HL175502-02
The award supports research on how mitochondrial dynamics influence inflammation in sepsis-induced acute lung injury, focusing on TLR4 signaling and mitochondrial fission, with the goal of developing new therapies.
Description
This project investigates the role of TLR4-mediated mitochondrial network remodeling in prolonging inflammation during sepsis-induced acute lung injury (ALI). It aims to define molecular mechanisms involving mitochondrial fission, mt-ROS production, and inflammatory pathways, and to test therapeutic strategies in pre-clinical mouse models to restore mitochondrial balance and reduce lung injury.