Award
National Institute of Neurological Disorders and Stroke 5R37NS102978-08
Noncanonical glutamate signaling in the origins of the migraine attack
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT
Award Amount
$656,560.00
Ceiling
$656,560.00
Awarded
February 11, 2026
Identifier
5R37NS102978-08
Research project funded by NINDS to investigate glutamate signaling and spreading depolarization mechanisms in migraine attacks, aiming to understand and potentially stop migraines.
Description
This project studies the origins of migraine attacks focusing on spreading depolarization (SD), the physiological correlate of migraine aura. Using imaging, electrophysiology, and genetic manipulation, the study examines the cerebral cortex at cellular resolution during SD initiation to generate insights into how migraines begin and how to stop them.