NIH Reporter #5R01NS119319-05

Locating the neural substrates for the flexor synergy after stroke

A NIH-funded research project to study neural circuits responsible for post-stroke muscle synergies using a monkey model, aiming to inform therapeutic interventions.

Description

This project aims to develop a monkey model to induce and study post-stroke muscle synergies, identify responsible neural circuits, and understand their control in health and post-stroke conditions. The research involves training monkeys on reaching tasks, implanting electrodes, inducing cortical lesions, and analyzing muscle activity, movement kinematics, and reflexes to elucidate the neuroanatomy of post-stroke synergies and pave the way for targeted therapies.

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