Award
National Institute of Allergy and Infectious Diseases 3R01AI175941-04S1
Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational households in Thailand
Recipient
Upstate Medical University
Award Amount
$94,253.00
Ceiling
$94,253.00
Awarded
July 14, 2026
Identifier
3R01AI175941-04S1
A research project funded by NIAID to study immune protection against dengue illness in a long-term cohort in Thailand, focusing on antibody profiles and exposure histories to identify correlates of protection.
Description
This study will leverage an established and uniquely long-term family cohort study for DENV in Thailand to define how the early immune environment to DENV, as shaped by maternally-transferred DENV antibodies and the timing and features of early DENV and non-DENV flavivirus exposures, shapes an individual’s future antibody-mediated immune profiles to DENV and subsequent risks of dengue illness. The research aims to identify immune correlates of durable, multi-serotypic protection against dengue illness, providing benchmarks for diagnostics, triage, and vaccines.