Award
National Institute on Aging 5R01AG084473-04
Role of glucose transport in Alzheimer's disease pathogenesis
Recipient
UNIV OF ARKANSAS FOR MED SCIS
Award Amount
$382,500.00
Ceiling
$382,500.00
Awarded
March 19, 2026
Identifier
5R01AG084473-04
Research project funded by the National Institute on Aging to study glucose transport defects in Alzheimer's disease, focusing on astrocyte function, inflammation, and ApoE4 genetic variant to identify potential therapies.
Description
This project examines how risk factors for Alzheimer’s, such as inflammation and ApoE4, affect brain energy utilization. It aims to understand how these factors contribute to mental deterioration and to identify potential chemical compounds for therapeutic development. The study focuses on the role of glucose transport in Alzheimer's disease pathogenesis, investigating the function of glucose transport proteins, astrocytes, inflammation, and the impact of the ApoE4 genetic variant, with the goal of identifying therapeutic strategies.