Award
National Heart, Lung, and Blood Institute 5R01HL179780-02
Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic Disease
Recipient
CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH, UNITED STATES
Award Amount
$728,435.00
Ceiling
$728,435.00
Awarded
March 04, 2026
Identifier
5R01HL179780-02
Research project funded by the National Heart Lung and Blood Institute to study the role of gut microbe-derived lipids in chronic inflammation related to cardiometabolic diseases, aiming to develop probiotic therapies.
Description
This project aims to explore how gut microbial-derived lipids, specifically N-acyl amides, influence cardiometabolic health by signaling through the host GPR119 receptor to modulate inflammation and metabolism. The hypothesis is that the microbial metabolite N-oleoyl serinol acts as a lipokine to suppress metainflammation, with potential therapeutic implications.