# NIH Reporter #4RF1MH136259-03

Dopaminergic Gut-Brain Signaling on Adolescent Reward Learning After Adversity: Toward New, Noninvasive Treatments for Depression and Anxiety

**Recipient:** University of California Los Angeles

**Award Amount:** $2,324,338.00
**Ceiling:** $2,324,338.00

**Awarded:** September 15, 2026

**Identifier:** 4RF1MH136259-03

This award supports research to identify gut-brain signaling pathways related to anxiety and depression in adolescents, study environmental risk factors, and develop novel microbiome-targeted therapeutics for mental health disorders.

### Description

The project aims to identify gut-brain signaling pathways underlying anxiety and depression in adolescents, examine environmental impacts, and develop microbiome-targeted therapeutics. It focuses on adolescent reward learning, neurodevelopment, and neuroimaging to translate findings into noninvasive treatments.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11301911)