Award
NIH Reporter #5R01HL174545-02
Roles for SGK1 in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT
Award Amount
$641,545.00
Ceiling
$641,545.00
Awarded
August 10, 2026
Identifier
5R01HL174545-02
This award funds research on the role of SGK1 in heart failure with preserved ejection fraction, aiming to understand molecular mechanisms and develop new therapies for cardiometabolic diseases.
Description
The project focuses on the role of serum glucocorticoid kinase 1 (SGK1) in cardiometabolic HFpEF, exploring its impact on cardiac function, metabolism, and systemic metabolic health. The research involves cardiac-specific targeting of SGK1 and PRAS40 in a mouse model, mechanistic studies in primary cardiomyocytes, and evaluation of a novel SGK1 inhibitory peptide. The studies aim to decipher molecular mechanisms contributing to HFpEF to develop novel therapeutic avenues and reduce mortality from cardiovascular and obesity-related diseases.