Award
NIH Reporter #5R01DK126892-04
The cellular molecular regulation of differing mechanisms of insulin resistance.
Recipient
Howard University, Washington, DC, United States
Award Amount
$345,992.00
Ceiling
$345,992.00
Awarded
August 23, 2025
Identifier
5R01DK126892-04
The award supports research on the cellular and molecular regulation of different mechanisms of insulin resistance using animal models to understand the impact of excess fat, sugar, and androgens, aiming to develop targeted therapies.
Description
This project studies three models of insulin resistance in an animal model to better understand the mechanisms involved in insulin resistance related to excess fat intake, excess sugar intake, and excess androgens. The research focuses on insulin resistance mechanisms, animal models, lipid and carbohydrate metabolism, and therapeutic interventions. The study aims to develop mouse models of hepatic insulin resistance and examine intersecting pathogenic mechanisms to inform targeted therapies.