Award
National Institute of Allergy and Infectious Diseases 1F31AI191539-01A1
Novel structural and functional insights into T cell metabolism in healthy and disease states
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
March 27, 2026
Identifier
1F31AI191539-01A1
Research project funded by NIAID to study T cell mitochondrial metabolism and its role in health and disease using cryo-electron tomography, aiming to improve understanding and therapeutic strategies.
Description
This project aims to visualize and analyze the mitochondrial ultrastructure and supercomplex organization in T cells during health and disease, particularly within a melanoma tumor microenvironment, using cryo-electron tomography. The research hypothesizes that T cell activation induces structural changes in respiratory complexes, contributing to metabolic dysfunction. The study will identify mitochondrial ultrastructure and supercomplex stoichiometry, advancing understanding of T cell pathology and informing structure-guided therapeutic interventions.