Award
National Institute of Allergy and Infectious Diseases 1R01AI196092-01
Decoding the role of Aire-expressing Thetis cells in peripheral self-tolerance
Recipient
Sloan-Kettering Inst Can Research, New York, NY, United States
Award Amount
$616,042.00
Ceiling
$616,042.00
Awarded
February 03, 2026
Identifier
1R01AI196092-01
This award funds research to understand how Aire-expressing Thetis cells contribute to peripheral immune tolerance, potentially revealing new mechanisms to prevent autoimmunity and improve therapies for autoimmune diseases, transplantation, and cancer.
Description
Establishing and maintaining immune tolerance to self-antigens is vital to prevent lethal autoimmunity. This project addresses the role of a novel lineage of Aire-expressing antigen-presenting cells (Thetis cells; TCs) in establishing and maintaining tolerance to self-antigens. The studies aim to establish a new framework for peripheral immune tolerance and identify novel pathways of immune regulation with broad therapeutic potential in autoimmunity, transplantation, and cancer.