Award
National Heart, Lung, and Blood Institute 5R01HL169515-03
Induction of myeloid-epithelial gap junctional channels to enhance host resilience against acute lung injury.
Recipient
Columbia University Health Sciences
Award Amount
$761,507.00
Ceiling
$761,507.00
Awarded
June 16, 2026
Identifier
5R01HL169515-03
NIH grant awarded to Columbia University Health Sciences to study and develop therapies enhancing host resilience against acute lung injury through gap junctional channels between myeloid cells and alveolar epithelium.
Description
This NIH research grant focuses on enhancing host resilience against acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) by studying gap junctional channels between myeloid cells and alveolar epithelium. The project involves evaluating alveolar gap junctional channels between airway-instilled bone marrow-derived monocytes and alveolar epithelium, investigating calcium communication and kinase activation, and exploring novel monocyte instillation therapy in the lung.