Award
NIH Reporter #1R01CA308965-01A1
Preclinical mouse models of liposarcoma for immuno-oncology applications
Recipient
University of Michigan at Ann Arbor
Award Amount
$609,997.00
Ceiling
$609,997.00
Awarded
August 26, 2026
Identifier
1R01CA308965-01A1
Development and validation of preclinical mouse models of liposarcoma to support immuno-oncology research, including creation of genetically-engineered models and testing of therapies.
Description
This project aims to develop and validate preclinical mouse models of liposarcoma (LPS) to facilitate immuno-oncology research. The study involves creating genetically-engineered mouse models that mimic human liposarcoma, establishing syngeneic cell lines, and testing therapeutic responses to immune checkpoint inhibitors and chemotherapy.