Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK146932-01
The role of the neuronal entero-pancreatic circuit in glucose metabolism
Recipient
University of Miami School of Medicine
Award Amount
$537,250.00
Ceiling
$537,250.00
Awarded
June 03, 2026
Identifier
1R01DK146932-01
Research project funded by NIDDK to study the neuronal entero-pancreatic circuit's influence on glucose metabolism and insulin secretion, aiming to develop therapeutic strategies for type 2 diabetes.
Description
This project investigates the neuronal entero-pancreatic circuit's role in glucose metabolism, focusing on how gut signals influence insulin secretion and blood glucose regulation. The research aims to elucidate mechanisms coupling gut sensing to enteric neurons, neurotransmission to pancreatic islet cells, and the overall impact on glucose homeostasis. Advanced genetic and imaging technologies, including intravital Ca2+ imaging and single nuclei sequencing, will be employed.