# NIH Reporter #5P01CA163227-12

Functional Interplay Between PARP, AR and DNA Damage

**Recipient:** Beth Israel Deaconess Medical Center

**Award Amount:** $812,190.00
**Ceiling:** $812,190.00

**Awarded:** September 16, 2026

**Identifier:** 5P01CA163227-12

NIH-funded research examining how PARP, androgen receptor signaling, BRCA1/BRCA2, and DNA damage interact in prostate cancer, with the goal of informing treatment strategies involving PARP inhibitors and AR-targeted therapies.

### Description

Project to elucidate the functional interplay between androgen receptor signaling, PARP genes and inhibitors, BRCA1 and BRCA2, and DNA damage to develop improved strategies for treating aggressive prostate cancer.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11419271)