Award
NIH Reporter #1R01CA299106-01A1
Canonical and alternative functions of low-density lipoprotein in multiple myeloma
Recipient
University of Arkansas for Medical Sciences
Award Amount
$401,971.00
Ceiling
$401,971.00
Awarded
August 14, 2026
Identifier
1R01CA299106-01A1
NIH awarded a grant to the University of Arkansas for Medical Sciences to investigate LDL's role in multiple myeloma progression and therapy resistance, including its immune effects, with a goal to develop new therapeutic strategies.
Description
This NIH grant project aims to study the role of low-density lipoprotein (LDL) in multiple myeloma (MM), focusing on LDL's functions in lipid transport and its role in immune modulation through small RNA transport. The research seeks to understand LDL's impact on MM growth, progression, therapeutic resistance, and the tumor microenvironment, using innovative pre-clinical models and testing LDL-lowering drugs with chemotherapy.